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AGENTS FOR GLAUCOMA
Glaucoma is a condition of the eye in which an elevation of the intraocular pressure (IOP) leads to progressive cupping and atrophy of the optic nerve head, deterioration of the visual fields, and, ultimately, to blindness. Primary open-angle glaucoma is the most common type of glaucoma. Angle-closure glaucoma and congenital glaucoma are treated primarily by surgical methods, although short-term drug therapy is used to decrease IOP prior to surgery.
Drugs used in the therapy of primary open-angle glaucoma include a variety of agents with different mechanisms of action. The therapeutic goal in treating glaucoma is reducing the elevated IOP, a major risk factor in the pathogenesis of glaucomatous visual field loss. The higher the level of IOP, the greater the likelihood of glaucomatous visual field toss and optic nerve damage. Reduction of IOP may be accomplished by: 1) Decreasing the rate of production of aqueous humor or 2) increasing the rate of outflow (drainage) of aqueous humor from the anterior chamber of the eye.
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